They are appearing at Mid & South East Northumberland Magistrates' Court on a range of charges.
Another man has been summonsed to appear before Newcastle Magistrates' Court in relation to sexual offences.
Deputy Chief Constable Steve Ashman said: "Today marks a milestone in this operation. Since the first allegations were made over a year ago we have painstakingly left no stone unturned in our efforts to investigate all allegations.
"We have worked closely with a range of other agencies including the local authority and CPS to reach this point. We are limited in what we can say as we must now protect the integrity of the criminal proceedings and must avoid any statements that could breach legal restrictions and put prosecutions at risk.
"To date, this part of the investigation has involved speaking to over 100 potential complainants, a dozen of whom have been identified as victims in relation to today’s charges. This has been done carefully with support from other professionals and I must commend them all for their bravery in working with us. The welfare of victims is our priority and we have worked closely with other agencies to ensure they have the appropriate support in place.
"Operation Sanctuary will not end. It is a wide ranging investigation into many different crimes of a sexual nature against vulnerable women and girls. Today’s charges are just one element of this.
"I would encourage anyone who wants to report such crimes to police to do so. They will be believed and they will be supported.
"We have had tremendous support from the public and businesses and we need this to continue. I would urge people to be vigilant and if something doesn't look or feel right I would ask them to contact us.
"Some people or groups may try to use Operation Sanctuary to build resentment. Our community has a history of harmonious relations and is one of tolerance. Anyone experiencing hate crime should report it to police and be reassured we will investigate thoroughly.
"By working together, we can continue to ensure out towns and cities are safe places to live, work and visit."
Those charged are:
1) Eisa Mousavi, 39, of Todds Nook, Newcastle has been charged with sexual assault by touching on a female 13 or over; intimidating a witness/juror/person assisting the investigation; rape of a female aged 16 or over; supplying or offering to supply a class B controlled drug; causing or inciting prostitution for gain.
2) Monjur Choudhury, 30, of Philip Place, Newcastle has been charged with permit use of premises for supply of drugs; supply or offer to supply class B controlled drugs; causing or inciting prostitution for gain.
3) Redwan Siddquee, 30, of West Road, Newcastle has been charged with causing or inciting prostitution for gain; supply or offering to supply a class B controlled drug.
4) Mohammed Hassan Ali, 32, of Bentinck Street, Newcastle has been charged with a sexual act on a female and possession of mephadrone with intent to supply.
5) Abdulhamid Minoyee, 31, of Gainsbrough Grove, Newcastle has been charged with rape of a female aged 16 or over; supply or offer to supply cannabis; sexual assault by touching a female 13 or over.
6) Ebrahim Ali, 38, of Wetherby Grove, Gateshead has been charged with supply or offer to supply a class B controlled drug; supply or offer to supply a class A controlled drug; trafficking within the UK for sexual exploitation; arrange child prostitution; rape of a female aged 16 or over.
7) Habibur Rahim, 32, of Kenilworth Road, Newcastle has been charged with sexual assault by touching a female 13 or over; administering a substance with intent; sexual assault by touching a female 13 or over; supply or offering to supply a class B controlled drug; supply or offer to supply cannabis; trafficking within the UK for sexual exploitation; causing or inciting prostitution for gain.
8) Ibrahim Rousel, 34, of Manor Gardens, Wardley has been charged with rape of a female aged 16 or over and administering a substance with intent.
9) Mohammed Khalique, 22, of Beaconsfield Street, Newcastle has been charged with rape of a female aged 16 or over; supply or offer to supply a class B controlled drug.
10) Mohammed Azram, 33, of Croydon Road, Newcastle has been charged with rape of a female aged 16 or over; supply of mephadrone; supply or offer to supply a class B controlled drug; sexual assault by touching a female aged 13 or over; trafficking within the UK for sexual exploitation; causing or inciting prostitution for gain.
11) Nadeem Aslam, 41, of Belle Grove West, Newcastle has been charged with possession of cannabis; possession of mephadrone; supply of mephadrone; permit the use of premises for supply of drugs; causing or inciting prostitution for gain.
12) Prabhat Nelli, 31, Corporation Road, Newcastle has been charged with supply or offer to supply a class B drug and causing or inciting prostitution for gain.
13) Taherul Alam, 29, of Normanton Terrace, Newcastle has been charged with supply or offer to supply a class B controlled drug; permit the use of premises to supply drugs; sexual assault by touching on a female 13 or over; causing or inciting prostitution for gain.
14) Yassar Hussain, 25, of Canning Street, Newcastle has been charged with rape of a female aged 16 or over; permit the use of premises to supply drugs; assault occasioning actual bodily harm; possession of mephadrone; possession of amphetamine; causing or inciting prostitution for gain.
15) Jahangir Zaman, 41, of Hadrian Road, Newcastle has been charged with supply or offer to supply a class B controlled drug and causing or inciting prostitution for gain.
16) Badrul Hussain, 34, of Drybeck Court, has been charged with rape of a female aged under 16; supply of mephadrone; permit the use of a premises to supply drugs and causing or inciting prostitution for gain.
17) Abdul Sabe, 37, of Dean House, Newcastle has been charged with possession of cannabis; trafficking within the UK for sexual exploitation; non-penatrative sexual activity with a girl 13 to 15; supply or offer to supply cannabis; sexual assault by touching a female 13 or over and administering a substance with intent.
18) Karzan Mohammed, 23, of Graingerville South, Newcastle has been charged with rape of a female under 16; falsely imprison/detain another; supply or offer to supply cannabis; assault occasioning actual bodily harm; administering a substance with intent; rape of a female aged 16 or over and trafficking within the UK for sexual exploitation.
19) Saiful Islam, 32, of Strathmore Crescent, Newcastle has been charged with rape of a female aged under 16 and supply or offer to supply cannabis.
20) Nashir Uddin, 33, of Joan Street, Newcastle has been charged with supply or offer to supply a class A controlled drug; supply of mephadrone; permit the use of premises for supply of drugs; rape of a female under 16; causing or inciting prostitution for gain; failing to surrender to custody/respond to bail.
21) A 34-year-old man, from Newcastle, has received a summons in relation to a sexual assault and administering a substance with intent.
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